Polymerases

Transcriptional polymerases:

      Replicate non damaged DNA in S phase

              Alpha

              Delta

              Epsilon

      Replicates mitochondrial DNA

                Gamma

      Lesion tolerant

              N K L E

      General transcription factors

          TFIID---Binds to TATA box, calls TFIIB

          TFIIB---Binds TFIID and calls RNA Polymerase II

          TFIIF---Binds to RNA polymerase II and keeps everything bound

          TFIIE---forms open complex

          TFIIH---Helicases phosphorylates carboxyl terminal domain of RNA pol II

Bacterial DNA Polymerases:

     Repair Enzymes

          DNA Polymerase I---Replaces primers

          DNA Polymerase II---

     Replication-

           DNA polymerase III---each cell has two, they go each way in the bacterial genome.

DNA polymerase α includes an RNA polymerase subunit that serves as the primase.  This enzyme usually has no exonuclease activity.

DNA polymerase δ serves the primary chromosomal replicative enzyme.